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Article

Etiology of Crohn's disease: many roads lead to autophagy.

Journal of molecular medicine (Berlin, Germany) - 1 Sept 2012

Lapaquette Pierre, Brest Patrick, Hofman Paul, Darfeuille-Michaud Arlette

Abstract excerpt

Crohn's disease is a complex multifactor diseases that occur in individuals with genetic predisposition in whom environmental and microbial triggers cause a deleterious chronic immune response. Susceptibility to Crohn's disease is influenced by common variants at many loci. Genetic studies have emphasized the role of host susceptibility in inflammatory bowel disease onset with the identification of about 100 risk...

Topics

Animals
Autophagy
Crohn Disease
GTP-Binding Proteins
Gastrointestinal Tract
Gene Expression Regulation
Genetic Predisposition to Disease
Humans
MicroRNAs
Polymorphism, Genetic

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PMID: 22797958
DOI: 10.1007/s00109-012-0934-8

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