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Article

Inflammatory bowel disease: dysfunction of autophagy?

Digestive diseases (Basel, Switzerland) - 1 Jan 2012

Scharl Michael, Rogler Gerhard

Abstract excerpt

Recent genome-wide association studies identified single nucleotide polymorphisms within gene loci, encoding autophagy genes, e.g. the autophagy-related 16-like 1 (ATG16L1) and the immunity-related GTPase family M (IRGM), as an important risk factor for the onset of chronic inflammatory diseases such as Crohn's disease (CD) or rheumatoid arthritis. CD is characterized by a breakdown of the intestinal epithelial...

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Identifiers

PMID: 23295687
DOI: 10.1159/000342588

Genes

IRGM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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