Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage.

doi:10.1128/AAC.00137-15

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Article

Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage.

Antimicrobial agents and chemotherapy - 1 Aug 2015

Alteri Claudia, Surdo Matteo, Bellocchi Maria Concetta, Saccomandi Patrizia, Continenza Fabio, Armenia Daniele, Parrotta Lucia, Carioti Luca, Costa Giosuè, Fourati Slim, Di Santo Fabiola, Scutari Rossana, Barbaliscia Silvia, Fedele Valentina, Carta Stefania, Balestra Emanuela, Alcaro Stefano, Marcelin Anne Genevieve, Calvez Vincent, Ceccherini-Silberstein Francesca, Artese Anna, Perno Carlo Federico, Svicher Valentina

Abstract excerpt

Incomplete APOBEC3G/F neutralization by a defective HIV-1Vif protein can promote genetic diversification by inducing G-to-A mutations in the HIV-1 genome. The HIV-1 Env V3 loop, critical for coreceptor usage, contains several putative APOBEC3G/F target sites. Here, we determined if APOBEC3G/F, in the presence of Vif-defective HIV-1 virus, can induce G-to-A mutations at V3 positions critical to modulation of CXCR4...

Topics

APOBEC Deaminases
Amino Acid Sequence
Amino Acid Substitution
Base Sequence
Cell Line
Cytidine Deaminase
Cytosine Deaminase
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HEK293 Cells

HIV Infections

HIV-1

Humans

Leukocytes, Mononuclear

Mutation

Receptors, CCR5

Receptors, CXCR4

Source

Open in PubMed Open full text

Identifiers

PMID: 26055363
DOI: 10.1128/AAC.00137-15
PMCID: PMC4505216

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage.PMID 26055363Read ↗

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