Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them All

doi:10.1016/j.jmb.2013.10.033

Article

Multiple APOBEC3 Restriction Factors for HIV-1 and One Vif to Rule Them All

2 Nov 2013

Abstract excerpt

Several members of the APOBEC3 family of cellular restriction factors provide intrinsic immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F, APOBEC3G, and APOBEC3H haplotypes II, V, and VII provide protection against HIV-1Δvif through hypermutation of the viral genome, inhibition of reverse transcription, and inhibition of viral DNA integration into the host genome. HIV-1 counteracts...

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