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HIV-1 Vif global diversity and possible APOBEC-mediated response since 1980

11 Dec 2024

Abstract excerpt

Abstract HIV-1 Vif’s principal function is to counter the antiretroviral activities of DNA-editing APOBEC3 cytidine deaminases. Unconstrained APOBEC3 activity introduces premature stop codons in HIV-1 genes and can lead to viral inactivation. To investigate the evolution and diversification of Vif over the HIV-1 pandemic and document evidence of APOBEC3-mediated pressure, we analyzed 4612 publicly available...

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Identifiers

PMID: 39886100
DOI: 10.1093/ve/veae108

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