Article
Long-term restriction by APOBEC3F selects human immunodeficiency virus type 1 variants with restored Vif function.
Journal of virology - 1 Oct 2010
Albin John S, Haché Guylaine, Hultquist Judd F, Brown William L, Harris Reuben S
Abstract excerpt
Tandem stop mutations K26X and H27X in human immunodeficiency virus type 1 (HIV-1) vif compromise virus replication in human T-cell lines that stably express APOBEC3F (A3F) or APOBEC3G (A3G). We previously reported that partial resistance to A3G could develop in these Vif-deficient viruses through a nucleotide A200-to-T/C transversion and a vpr null mutation, but these isolates were still susceptible to...
Topics
- APOBEC-3G Deaminase
- Alleles
- Base Sequence
- Cell Line
- Cytidine Deaminase
- Cytosine Deaminase
- DNA Primers
- DNA, Viral
- Genes, vif
- HIV-1
- Host-Pathogen Interactions
- Humans
- Mutagenesis, Site-Directed
- Mutation