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Article

Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.

Science advances - 24 Jul 2026

Langley Caroline A, Lilly Michelle, Malik Harmit S, Emerman Michael

Abstract excerpt

Host immune factors shape viral evolution. The HIV-1 viral infectivity factor (Vif) protein counteracts host Apolipoprotein B Messenger RNA Editing Enzyme Catalytic Polypeptide-like 3 (A3G) to ensure productive infection. Using deep mutational scanning across two divergent HIV-1 Vif proteins, we systematically mapped and compared the mutational landscapes governing Vif antagonism of A3G. These high-resolution...

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Topics

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Share to APOBEC-3G Deaminase
Share to Epistasis, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Fitness

Share to Host-Pathogen Interactions

Share to Protein Binding

Share to vif Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 42490454
DOI: 10.1126/sciadv.aed4872
PMCID: PMC13394466

Genes

APOBEC3G

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins.PMID 42490454Read ↗

Strain-Specific Epistasis Shapes Fitness Landscapes of APOBEC3G Antagonism By HIV-1 Vif ProteinsSemantic proximity Read ↗

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