Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes.

doi:10.1074/jbc.M110.173286

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Article

Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes.

The Journal of biological chemistry - 12 Nov 2010

Iwabu Yukie, Kinomoto Masanobu, Tatsumi Masashi, Fujita Hideaki, Shimura Mari, Tanaka Yoshitaka, Ishizaka Yukihito, Nolan David, Mallal Simon, Sata Tetsutaro, Tokunaga Kenzo

Abstract excerpt

Antiretroviral cytidine deaminase APOBEC3G, which is abundantly expressed in peripheral blood lymphocytes and macrophages, strongly protects these cells against HIV-1 infection. The HIV-1 Vif protein overcomes this antiviral effect by enhancing proteasome-mediated APOBEC3G degradation and is key for maintaining viral infectivity. The 579-bp-long vif gene displays high genetic diversity among HIV-1 subtypes....

Topics

APOBEC-3G Deaminase
Amino Acid Sequence
Binding Sites
Cells, Cultured
Cytidine Deaminase
Cytosine Deaminase
HEK293 Cells
HIV-1
Humans
Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoprecipitation

Molecular Sequence Data

Mutation

Phylogeny

Protein Binding

Sequence Homology, Amino Acid

Species Specificity

Virion

Source

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Identifiers

PMID: 20833716
DOI: 10.1074/jbc.M110.173286
PMCID: PMC2975159

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