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Article

Hereditary Diffuse Gastric Cancer: Approaches to Screening, Surveillance, and Treatment.

Annual review of medicine - 27 Jan 2021

Pilonis Nastazja Dagny, Tischkowitz Marc, Fitzgerald Rebecca C, di Pietro Massimiliano

Abstract excerpt

Hereditary diffuse gastric cancer (HDGC) is a cancer syndrome associated with a significant lifetime risk of diffuse gastric cancer (DGC), a malignancy characterized by late clinical presentation and poor prognosis, as well as lobular breast cancer. HDGC is linked to germline pathogenic variants in the E-cadherin gene (CDH1) that are inherited in an autosomal dominant pattern; however, in many families with DGC...

Topics

Combined Modality Therapy
Early Detection of Cancer
Genetic Predisposition to Disease
Humans
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 33217247
DOI: 10.1146/annurev-med-051019-103216

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