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Article

Functional analyses of polymorphic variants of human terminal deoxynucleotidyl transferase.

Genes and immunity - 1 Sept 2015

Troshchynsky A, Dzneladze I, Chen L, Sheng Y, Saridakis V, Wu G E

Abstract excerpt

Human terminal deoxynucleotidyl transferase (hTdT) is a DNA polymerase that functions to generate diversity in the adaptive immune system. Here, we focus on the function of naturally occurring single-nucleotide polymorphisms (SNPs) of hTdT to evaluate their role in genetic-generated immune variation. The data demonstrate that the genetic variations generated by the hTdT SNPs will vary the human immune repertoire...

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Identifiers

PMID: 26043173
DOI: 10.1038/gene.2015.19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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