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Article

Distinct and Opposite Activities of Human Terminal Deoxynucleotidyltransferase Splice Variants

1 Sept 2004

Abstract excerpt

Evidence for potential human TdT (hTdT) isoforms derived from hTdT genomic sequences led us to identify the short isoform (hTdTS), as well as mature long transcripts containing exon XII (hTdTL1) and another including exon VII (hTdTL2) in lymphoid cells. Normal B and T lymphocytes express exclusively hTdTS and hTdTL2, whereas hTdTL1 expression appears to be restricted to transformed lymphoid cell lines. In in...

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PMID: 15356150
DOI: 10.4049/jimmunol.173.6.4009

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