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Article

The Impact of SNP-Induced Amino Acid Substitutions L19P and G66R in the dRP-Lyase Domain of Human DNA Polymerase β on Enzyme Activities.

International journal of molecular sciences - 10 Apr 2024

Kladova Olga A, Tyugashev Timofey E, Yakimov Denis V, Mikushina Elena S, Novopashina Daria S, Kuznetsov Nikita A, Kuznetsova Aleksandra A

Abstract excerpt

Base excision repair (BER), which involves the sequential activity of DNA glycosylases, apurinic/apyrimidinic endonucleases, DNA polymerases, and DNA ligases, is one of the enzymatic systems that preserve the integrity of the genome. Normal BER is effective, but due to single-nucleotide polymorphisms (SNPs), the enzymes themselves-whose main function is to identify and eliminate damaged bases-can undergo amino...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38673769
DOI: 10.3390/ijms25084182
PMCID: PMC11050361

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