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Article

Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes

27 Aug 1993

Abstract excerpt

During the assembly of immunoglobulin and T cell receptor variable region genes from variable (V), diversity (D), and joining (J) segments, the germline-encoded repertoire is further diversified by processes that include the template-independent addition of nucleotides (N regions) at gene segment junctions. Terminal deoxynucleotidyl transferase (TdT)-deficient lymphocytes had no N regions in their variable region...

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PMID: 8356451
DOI: 10.1126/science.8356451

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