Article
Whole Genome Sequencing Investigation of a Tuberculosis Outbreak in Port-au-Prince, Haiti Caused by a Strain with a "Low-Level" rpoB Mutation L511P - Insights into a Mechanism of Resistance Escalation.
PloS one - 1 Jan 2015
Ocheretina Oksana, Shen Lishuang, Escuyer Vincent E, Mabou Marie-Marcelle, Royal-Mardi Gertrude, Collins Sean E, Pape Jean W, Fitzgerald Daniel W
Abstract excerpt
The World Health Organization recommends diagnosing Multidrug-Resistant Tuberculosis (MDR-TB) in high burden countries by detection of mutations in Rifampin (RIF) Resistance Determining Region of Mycobacterium tuberculosis rpoB gene with rapid molecular tests GeneXpert MTB/RIF and Hain MTBDRplus. Such mutations are found in >95% of Mycobacterium tuberculosis strains resistant to RIF by conventional culture-based...
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