Article
Low-Level Rifampin Resistance and rpoB Mutations in Mycobacterium tuberculosis: an Analysis of Whole-Genome Sequencing and Drug Susceptibility Test Data in New York.
Journal of clinical microbiology - 19 Mar 2021
Shea Joseph, Halse Tanya A, Kohlerschmidt Donna, Lapierre Pascal, Modestil Herns A, Kearns Cheryl H, Dworkin Felicia F, Rakeman Jennifer L, Escuyer Vincent, Musser Kimberlee A
Abstract excerpt
Rapid and reliable detection of rifampin (RIF) resistance is critical for the diagnosis and treatment of drug-resistant and multidrug-resistant (MDR) tuberculosis. Discordant RIF phenotype/genotype susceptibility results remain a challenge due to the presence of rpoB mutations that do not confer high levels of RIF resistance, as have been exhibited in strains with mutations such as Ser450Leu. These strains,...
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