Article
Mutations in rpoB and katG genes and the inhA operon in multidrug-resistant Mycobacterium tuberculosis isolates from Zambia.
Journal of global antimicrobial resistance - 1 Sept 2020
Solo Eddie S, Nakajima Chie, Kaile Trevor, Bwalya Precious, Mbulo Grace, Fukushima Yukari, Chila Sylvia, Kapata Nanthan, Shah Yogendra, Suzuki Yasuhiko
Abstract excerpt
OBJECTIVES: It is established that resistance to rifampicin (RIF) in 90% of RIF-resistant Mycobacterium tuberculosis isolates is attributable to point mutations in the rpoB gene, whilst 50-95% of M. tuberculosis resistance to isoniazid (INH) is caused by mutations in the katG gene. However, the patterns and frequencies of mutations vary by geographical region. In Zambia, the genetic mechanisms of resistance of M....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.