Article
Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.
Journal of clinical microbiology - 1 May 2018
Maningi Nontuthuko E, Daum Luke T, Rodriguez John D, Said Halima M, Peters Remco P H, Sekyere John Osei, Fischer Gerald W, Chambers James P, Fourie P Bernard
Abstract excerpt
Modern advances in genomics provide an opportunity to reinterpret historical bacterial culture collections. In this study, genotypic antibiotic resistance profiles of Mycobacterium tuberculosis isolates from a historical 20-year-old multidrug-resistant tuberculosis (MDR-TB) culture collection in South Africa are described. DNA samples extracted from the phenotypically MDR-TB isolates (n = 240) were assayed by...
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