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Article

Genetic mechanisms of co-emergence of INH-resistant Mycobacterium tuberculosis strains during the standard course of antituberculosis therapy.

Microbiology spectrum - 2 Apr 2024

Tafess Ketema, Ng Timothy Ting-Leung, Tam Kingsley King-Gee, Leung Kenneth Siu-Sing, Leung Jake Siu-Lun, Lee Lam-Kwong, Lao Hiu Yin, Chan Chloe Toi-Mei, Yam Wing-Cheong, Wong Samson Sai Yin, Lau Terrence Chi-Kwong, Siu Gilman Kit-Hang

Abstract excerpt

The incidence of isoniazid (INH) resistant Mycobacterium tuberculosis is increasing globally. This study aimed to identify the molecular mechanisms behind the development of INH resistance in M. tuberculosis strains collected from the same patients during the standard course of treatment. Three M. tuberculosis strains were collected from a patient before and during antituberculosis (anti-TB) therapy. The strains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38466098
DOI: 10.1128/spectrum.02133-23
PMCID: PMC10986572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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