Article
MDR M. tuberculosis outbreak clone in Eswatini missed by Xpert has elevated bedaquiline resistance dated to the pre-treatment era.
Genome medicine - 25 Nov 2020
Beckert Patrick, Sanchez-Padilla Elisabeth, Merker Matthias, Dreyer Viola, Kohl Thomas A, Utpatel Christian, Köser Claudio U, Barilar Ivan, Ismail Nazir, Omar Shaheed Vally, Klopper Marisa, Warren Robin M, Hoffmann Harald, Maphalala Gugu, Ardizzoni Elisa, de Jong Bouke C, Kerschberger Bernhard, Schramm Birgit, Andres Sönke, Kranzer Katharina, Maurer Florian P, Bonnet Maryline, Niemann Stefan
Abstract excerpt
BACKGROUND: Multidrug-resistant (MDR) Mycobacterium tuberculosis complex strains not detected by commercial molecular drug susceptibility testing (mDST) assays due to the RpoB I491F resistance mutation are threatening the control of MDR tuberculosis (MDR-TB) in Eswatini. METHODS: We investigate the evolution and spread of MDR strains in Eswatini with a focus on bedaquiline (BDQ) and clofazimine (CFZ) resistance...
Topics
- Antitubercular Agents
- Bacterial Proteins
- Clone Cells
- Diarylquinolines
- Disease Outbreaks
- Eswatini
- Humans
- Microbial Sensitivity Tests