Article
Vertebrate Smoothened functions at the primary cilium.
Nature - 13 Oct 2005
Corbit Kevin C, Aanstad Pia, Singla Veena, Norman Andrew R, Stainier Didier Y R, Reiter Jeremy F
Abstract excerpt
The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedgehog (Hh) pathway has hinted at a functional connection between cilia and Hh signal transduction. Here we show that mammalian Smoothened (Smo), a seven-transmembrane protein essential for Hh signalling, is expressed on the primary cilium. This ciliary expression is regulated by Hh pathway activity; Sonic hedgehog or...
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