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Article

Intraflagellar transport is deeply integrated in hedgehog signaling.

Molecular biology of the cell - 15 May 2018

Eguether Thibaut, Cordelieres Fabrice P, Pazour Gregory J

Abstract excerpt

The vertebrate hedgehog pathway is organized in primary cilia, and hedgehog components relocate into or out of cilia during signaling. Defects in intraflagellar transport (IFT) typically disrupt ciliary assembly and attenuate hedgehog signaling. Determining whether IFT drives the movement of hedgehog components is difficult due to the requirement of IFT for building cilia. Unlike most IFT proteins, IFT27 is...

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Share to Biological Transport
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29540531
DOI: 10.1091/mbc.E17-10-0600
PMCID: PMC5935068

Genes

IFT27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Intraflagellar transport is deeply integrated in hedgehog signaling.PMID 29540531Read ↗

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