Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.

eLife - 12 Jun 2014

Yue Shen, Tang Liu-Ya, Tang Ying, Tang Yi, Shen Qiu-Hong, Ding Jie, Chen Yan, Zhang Zengdi, Yu Ting-Ting, Zhang Ying E, Cheng Steven Y

Abstract excerpt

Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two 'PPXY' motifs, that direct it to degradation in lysosomes. These signals are recognized by two HECT-domain ubiquitin E3 ligases, Smurf1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Endocytosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

Share to Hedgehog Proteins

Share to Microscopy, Confocal

Share to Patched-1 Receptor

Share to Patched Receptors

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 24925320
DOI: 10.7554/eLife.02555
PMCID: PMC4080449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.PMID 24925320Read ↗

Endocytic recycling protein EHD1 regulates primary cilia morphogenesis and SHH signaling during neural tube development.Semantic proximity Read ↗

Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog.Semantic proximity Read ↗

The role of ciliary trafficking in Hedgehog receptor signalingSemantic proximity Read ↗

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking.Semantic proximity Read ↗

Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium.Semantic proximity Read ↗

Patched1 is required in neural crest cells for the prevention of orofacial clefts.Semantic proximity Read ↗

<i>PTCH1</i> mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesisSemantic proximity Read ↗

Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.Semantic proximity Read ↗

Rab23: what exactly does it traffic?Semantic proximity Read ↗

The primary cilium as a Hedgehog signal transduction machine.Semantic proximity Read ↗

Ptch2 mediates the Shh response in Ptch1-/- cells.Semantic proximity Read ↗

Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.