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Article

Hedgehog-stimulated chemotaxis is mediated by smoothened located outside the primary cilium.

Science signaling - 21 Aug 2012

Bijlsma Maarten F, Damhofer Helene, Roelink Henk

Abstract excerpt

Regulation of the Hedgehog (Hh) pathway relies on an interaction of two receptors. In the absence of Hh, Patched1 (Ptch1) inhibits the pathway. Binding of the ligand Hh to Ptch1 stimulates the localization of the activating receptor Smoothened (Smo) to the primary cilium, which is required for the transcriptional Hh response. Hh can also induce chemotaxis through a nontranscriptional pathway. We assessed the...

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Share to Chemotaxis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hedgehog Proteins

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Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 22912493
DOI: 10.1126/scisignal.2002798
PMCID: PMC4557959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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