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Article

In vitro and in vivo fitness costs associated with Mycobacterium tuberculosis RpoB mutation H526D.

Future microbiology - 1 Jul 2017

Rifat Dalin, Campodónico Victoria L, Tao Jing, Miller James A, Alp Alpaslan, Yao Yufeng, Karakousis Petros C

Abstract excerpt

AIM: There is controversy regarding the potential fitness costs of rifampicin (RIF) resistance-conferring mutations in the Mycobacterium tuberculosis (Mtb) rpoB gene. We characterized the pathogenicity of an Mtb RpoB H526D mutant. MATERIALS & METHODS: A mutant containing the RpoB H526D mutation was isolated from wild-type Mtb grown on RIF-containing plates and complemented for determination of in vitro and in...

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Source

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Identifiers

PMID: 28343421
DOI: 10.2217/fmb-2017-0022
PMCID: PMC5506874

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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