Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D

19 Mar 2018

Abstract excerpt

Background: Mycobacterium tuberculosis (Mtb) rpoB mutations are associated with global metabolic remodeling. However, the net effects of rpoB mutations on Mtb physiology, metabolism and function are not completely understood. Based on previous work, we hypothesized that changes in the expression of cell wall molecules in Mtb mutant RpoB 526D lead to changes in cell wall permeability and to altered resistance to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Molecular Research
Share to Mycobacterium research and diagnosis
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29616007
DOI: 10.3389/fmicb.2018.00494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526DPMID 29616007Read ↗

Rifampin Resistance Mutations Are Associated with Broad Chemical Remodeling of Mycobacterium tuberculosisSemantic proximity Read ↗

Cell Wall Proteomics Reveal Phenotypic Adaption of Drug-Resistant Mycobacterium smegmatis to Subinhibitory Rifampicin ExposureSemantic proximity Read ↗

Altered fatty acid metabolism due to rifampicin-resistance conferring mutations in the rpoB Gene of Mycobacterium tuberculosis: mapping the potential of pharmaco-metabolomics for global health and personalized medicine.Semantic proximity Read ↗

Upregulation of the Phthiocerol Dimycocerosate Biosynthetic Pathway by Rifampin-Resistant,<i>rpoB</i>Mutant Mycobacterium tuberculosisSemantic proximity Read ↗

Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility.Semantic proximity Read ↗

In vitro and in vivo fitness costs associated with Mycobacterium tuberculosis RpoB mutation H526D.Semantic proximity Read ↗

Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.Semantic proximity Read ↗

The impact of drug resistance on <i>Mycobacterium tuberculosis</i> physiology: what can we learn from rifampicin?Semantic proximity Read ↗

A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism.Semantic proximity Read ↗

Mutations in <i>rpoB</i> that confer rifampicin resistance can alter levels of peptidoglycan precursors and affect β-lactam susceptibilitySemantic proximity Read ↗

Cell-Envelope Remodeling as a Determinant of Phenotypic Antibacterial Tolerance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Expression Dysregulation as a Mediator of Fitness Costs in Antibiotic Resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.