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Mutations in <i>rpoB</i> that confer rifampicin resistance can alter levels of peptidoglycan precursors and affect β-lactam susceptibility

2022-11-15

Abstract excerpt

Bacteria can adapt to stressful conditions through mutations affecting the RNA polymerase core subunits that lead to beneficial changes in transcription. In response to selection with rifampicin (RIF), mutations arise in the RIF resistance determining region (RRDR) of rpoB that reduce antibiotic binding. These changes can also alter transcription and thereby have pleiotropic effects on bacterial fitness. Here, we...

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Literature Corpus work
61218ca3-ed4e-58d0-8249-94707d5d1ee9
DOI
10.1101/2022.11.14.516545
Open publication

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Mutations in <i>rpoB</i> that confer rifampicin resistance can alter levels of peptidoglycan precursors and affect β-lactam susceptibilityDOI 10.1101/2022.11.14.516545
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