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Article

Focused antibody response to influenza linked to antigenic drift

26 May 2015

Abstract excerpt

The selective pressure that drives antigenic changes in influenza viruses is thought to originate from the human immune response. Here, we have characterized the B cell repertoire from a previously vaccinated donor whose serum had reduced neutralizing activity against the recently evolved clade 6B H1N1pdm09 viruses. While the response was markedly polyclonal, 88% of clones failed to recognize clade 6B viruses;...

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Identifiers

PMID: 26011643
DOI: 10.1172/jci81104

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