Article

Memory T and B cells with recognition of avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccines

2025-04-29

Abstract excerpt

Immunisation remains the most cost-effective mechanism to combat global influenza infection and is widely employed against seasonal influenza viruses. Zoonotic transmission of avian influenza A viruses represents a significant threat to human health given the lack of population level immunity, which could translate into an influenza pandemic. Therefore, there is a need to better understand pre-existing human immun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be84f50d-7cdc-5379-9895-441ff8f80ddf
DOI: 10.1101/2025.04.28.651131

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Memory T and B cells with recognition of avian influenza hemagglutinins are poorly responsive to existing seasonal influenza vaccinesDOI 10.1101/2025.04.28.651131Read

Seasonal Influenza Exposure Elicits Functional Antibody and T-cell Responses to A(H5) Influenza Viruses in HumansSemantic proximity Read

Cross-reactive CD4+ T cell responses towards seasonal and avian influenzaSemantic proximity Read

Cross-reactive human antibody responses to H5N1 influenza virus neuraminidase are shaped by immune historySemantic proximity Read

Targets of influenza human T-cell response are mostly conserved in H5N1Semantic proximity Read

Targets of influenza Human T cell response are mostly conserved in H5N1Semantic proximity Read

Neuraminidase-Based Cross-Protective Immunity against H5N1 Influenza Viruses in HumansSemantic proximity Read

Naturally Occurring Antibodies in Humans Can Neutralize a Variety of Influenza Virus Strains, Including H3, H1, H2, and H5Semantic proximity Read

CD 8+ T cell epitope conservation in emerging H 5 N 1 viruses suggests global protectionSemantic proximity Read

A prevalent focused human antibody response to the influenza hemagglutinin head interfaceSemantic proximity Read

A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interfaceSemantic proximity Read

The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccinesSemantic proximity Read

H5N1 influenza binding and cell entry via human class II MHC, and blocking by cross-reactive antibodiesSemantic proximity Read