Article
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations.
The Journal of clinical investigation - 1 Apr 2016
Thornburg Natalie J, Zhang Heng, Bangaru Sandhya, Sapparapu Gopal, Kose Nurgun, Lampley Rebecca M, Bombardi Robin G, Yu Yingchun, Graham Stephen, Branchizio Andre, Yoder Sandra M, Rock Michael T, Creech C Buddy, Edwards Kathryn M, Lee David, Li Sheng, Wilson Ian A, García-Sastre Adolfo, Albrecht Randy A, Crowe James E
Abstract excerpt
Avian H7N9 influenza viruses are group 2 influenza A viruses that have been identified as the etiologic agent for a current major outbreak that began in China in 2013 and may pose a pandemic threat. Here, we examined the human H7-reactive antibody response in 75 recipients of a monovalent inactivated A/Shanghai/02/2013 H7N9 vaccine. After 2 doses of vaccine, the majority of donors had memory B cells that secreted...
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