Article
Human monoclonal antibodies broadly neutralizing against influenza B virus.
PLoS pathogens - 1 Feb 2013
Yasugi Mayo, Kubota-Koketsu Ritsuko, Yamashita Akifumi, Kawashita Norihito, Du Anariwa, Sasaki Tadahiro, Nishimura Mitsuhiro, Misaki Ryo, Kuhara Motoki, Boonsathorn Naphatsawan, Fujiyama Kazuhito, Okuno Yoshinobu, Nakaya Takaaki, Ikuta Kazuyoshi
Abstract excerpt
Influenza virus has the ability to evade host immune surveillance through rapid viral genetic drift and reassortment; therefore, it remains a continuous public health threat. The development of vaccines producing broadly reactive antibodies, as well as therapeutic strategies using human neutralizing monoclonal antibodies (HuMAbs) with global reactivity, has been gathering great interest recently. Here, three...
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