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Article

Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma.

Nature communications - 15 Jul 2023

Abbas Sujath, Pich Oriol, Devonshire Ginny, Zamani Shahriar A, Katz-Summercorn Annalise, Killcoyne Sarah, Cheah Calvin, Nutzinger Barbara, Grehan Nicola, Lopez-Bigas Nuria, Fitzgerald Rebecca C, Secrier Maria

Abstract excerpt

A variety of mutational processes drive cancer development, but their dynamics across the entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood. We explore the mutagenic processes shaping oesophageal adenocarcinoma tumorigenesis in 997 instances comprising distinct stages of this malignancy, from Barrett Oesophagus to primary tumours and advanced metastatic disease. The mutational...

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Source

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Identifiers

PMID: 37454136
DOI: 10.1038/s41467-023-39957-6
PMCID: PMC10349863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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