Article
Elucidating the genomic architecture of Asian EGFR-mutant lung adenocarcinoma through multi-region exome sequencing.
Nature communications - 15 Jan 2018
Nahar Rahul, Zhai Weiwei, Zhang Tong, Takano Angela, Khng Alexis J, Lee Yin Yeng, Liu Xingliang, Lim Chong Hee, Koh Tina P T, Aung Zaw Win, Lim Tony Kiat Hon, Veeravalli Lavanya, Yuan Ju, Teo Audrey S M, Chan Cheryl X, Poh Huay Mei, Chua Ivan M L, Liew Audrey Ann, Lau Dawn Ping Xi, Kwang Xue Lin, Toh Chee Keong, Lim Wan-Teck, Lim Bing, Tam Wai Leong, Tan Eng-Huat, Hillmer Axel M, Tan Daniel S W
Abstract excerpt
EGFR-mutant lung adenocarcinomas (LUAD) display diverse clinical trajectories and are characterized by rapid but short-lived responses to EGFR tyrosine kinase inhibitors (TKIs). Through sequencing of 79 spatially distinct regions from 16 early stage tumors, we show that despite low mutation burdens, EGFR-mutant Asian LUADs unexpectedly exhibit a complex genomic landscape with frequent and early whole-genome...
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