The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy.

doi:10.1158/0008-5472.CAN-21-0653

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Article

The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy.

Cancer research - 1 Oct 2021

Hirata Hidenari, Niida Atsushi, Kakiuchi Nobuyuki, Uchi Ryutaro, Sugimachi Keishi, Masuda Takaaki, Saito Tomoko, Kageyama Shun-Ichiro, Motomura Yushi, Ito Shuhei, Yoshitake Tadamasa, Tsurumaru Daisuke, Nishimuta Yusuke, Yokoyama Akira, Hasegawa Takanori, Chiba Kenichi, Shiraishi Yuichi, Du Junyan, Miura Fumihito, Morita Masaru, Toh Yasushi, Hirakawa Masakazu, Shioyama Yoshiyuki, Ito Takashi, Akimoto Tetsuo, Miyano Satoru, Shibata Tatsuhiro, Mori Masaki, Suzuki Yutaka, Ogawa Seishi, Ishigami Kousei, Mimori Koshi

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) often recurs after chemoradiotherapy, and the prognosis of ESCC after chemoradiotherapy has not improved over the past few decades. The mutation process in chemoradiotherapy-resistant clones and the functional relevance of genetic alterations remain unclear. To address these problems, we performed whole-exome sequencing of 52 tumor samples from 33 patients with ESCC who...

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PMID: 34413060
DOI: 10.1158/0008-5472.CAN-21-0653

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