Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.

Current opinion in rheumatology - 1 Jul 2015

Tran Tri M, Colbert Robert A

Abstract excerpt

PURPOSE OF REVIEW: To review the recent developments in our understanding of endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) function in relation to its role in major histocompatibility complex (MHC) class I peptide presentation and human leukocyte antigen (HLA) class I-associated diseases. RECENT FINDINGS: ERAP1 polymorphisms exhibiting loss-of-function have been associated with protection from AS. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases
Share to Genetic Predisposition to Disease
Share to Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class I

Share to HLA-B27 Antigen

Share to Minor Histocompatibility Antigens

Share to Polymorphism, Single Nucleotide

Share to Rheumatic Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 26002027
DOI: 10.1097/BOR.0000000000000188
PMCID: PMC4495904

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endoplasmic reticulum aminopeptidase 1 and rheumatic disease: functional variation.PMID 26002027Read ↗

Endoplasmic reticulum-associated amino-peptidase 1 and rheumatic disease: genetics.Semantic proximity Read ↗

ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role.Semantic proximity Read ↗

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.Semantic proximity Read ↗

Molecular and pathogenic effects of endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 in MHC-I-associated inflammatory disorders: Towards a unifying view.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidases: Biology and pathogenic potential.Semantic proximity Read ↗

Structural and biochemical insights into the association between ERAP1 polymorphism and autoimmune diseases.Semantic proximity Read ↗

Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo.Semantic proximity Read ↗

The role of polymorphic ERAP1 in autoinflammatory disease.Semantic proximity Read ↗

The Role of Aminopeptidase ERAP1 in Human Pathology—A ReviewSemantic proximity Read ↗

ERAP1 and ankylosing spondylitis.Semantic proximity Read ↗

ERAP1: a potential therapeutic target for a myriad of diseasesSemantic proximity Read ↗

Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.