CYP2D6 genetic polymorphisms and their relevance for poisoning due to amfetamines, opioid analgesics and antidepressants.

doi:10.3109/15563650.2015.1049355

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Article

CYP2D6 genetic polymorphisms and their relevance for poisoning due to amfetamines, opioid analgesics and antidepressants.

Clinical toxicology (Philadelphia, Pa.) - 1 Jul 2015

Haufroid Vincent, Hantson Philippe

Abstract excerpt

INTRODUCTION: Cytochrome P450 2D6 (CYP2D6) is a member of the cytochrome P450 (CYP) superfamily involved in the biotransformation of drugs and substances of abuse encountered in clinical toxicology. Among the CYP superfamily, the CYP2D6 gene is considered as the most polymorphic as more than 105 different alleles have been identified so far. CYP2D6 genetic polymorphisms have the potential to affect the toxicity...

Topics

Amphetamines
Analgesics, Opioid
Antidepressive Agents
Biotransformation
Cytochrome P-450 CYP2D6
Drug Overdose
Genetic Predisposition to Disease
Humans
Phenotype
Poisoning
Polymorphism, Genetic
Risk Assessment
Risk Factors
Toxicogenetics

Source

Open in PubMed

Identifiers

PMID: 25998998
DOI: 10.3109/15563650.2015.1049355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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