Article
[Importance of genetic polymorphism of cytochrome P450 isoenzymes for the choice and regimes of antidepressant and antipsychotic dosing on an individual basis].
Klinicheskaia meditsina - 1 Jan 2008
Savel'eva M I, Sychev D A, Kazakov R E, Ignat'ev I V, Tishenova A, Gasanov N A, Ramenskaia G V, Kukes V G
Abstract excerpt
Polymorphism of P450 2D6 (CYP2D6) gene is one of the causes of altered activity of enzymes controlling metabolism of medicinal products (MP), specifically increasing and decreasing biotransformation of xenobiotics. These changes result either in a rise or in a fall of plasma MP; in the former case adverse effects (AE) of MPs are likely to arise, in the latter xenobiotic therapy may prove inefficient. Drug...
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