Article

Influence of combined CYP2C19 and CYP2D6 phenotypes on adverse drug reactions in patients with major depressive disorder: a clinical cohort study

2025-06-30

Abstract excerpt

<title>Abstract</title> <p> Variants in cytochrome P450 enzymes are known risk factors for developing adverse drug reactions (ADR). Most antidepressants (AD) are simultaneously metabolized by major or minor pathway of CYP2C19 and CYP2D6, resulting in a complex interplay of metabolites. This study is one of the first to investigate and demonstrate the combined CYP 2C19/2D6 functional metabolic status as a risk fa...

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Literature Corpus work: bc0acad2-ba4a-5ad3-a2a6-2ff4ffb3ef1d
DOI: 10.21203/rs.3.rs-6406316/v1

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