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Article

Fatal intoxication cases: cytochrome P450 2D6 and 2C19 genotype distributions.

European journal of clinical pharmacology - 1 Oct 2004

Zackrisson A L, Holmgren P, Gladh A B, Ahlner J, Lindblom B

Abstract excerpt

OBJECTIVE: Many commonly used pharmaceuticals, such as antidepressants and neuroleptics as well as some illegal drugs, are metabolised by the cytochrome P450 enzyme debrisoquine 4-hydroxylase (CYP2D6). Of Caucasians, 7-10% lack this enzyme, which can, upon administration of drugs in normal therapeutic doses, lead to adverse reactions and unexpected intoxication, leading in turn even to a fatal outcome in some...

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PMID: 15349706
DOI: 10.1007/s00228-004-0800-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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