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Article

MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?

1 Jan 2012

Abstract excerpt

In vitro human studies show that the metabolism of most amphetamine-like psychostimulants is regulated by the polymorphic cytochrome P450 isozyme CYP2D6. Two compounds, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA), were selected as archetypes to discuss the translation and clinical significance of in vitro to in vivo findings. Both compounds were chosen based on their differential interaction with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23162568
DOI: 10.3389/fgene.2012.00235

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