Article
Newer antidepressants and the cytochrome P450 system.
The American journal of psychiatry - 1 Mar 1996
Nemeroff C B, DeVane C L, Pollock B G
Abstract excerpt
OBJECTIVE: This review evaluates the in vitro and in vivo evidence for inhibition of cytochrome P450 enzymes by the newer antidepressants and provides clinical recommendations for avoiding and managing drug interactions. METHOD: The international literature on the cytochrome P450 system and related drug interactions from 1966 to 1995 was reviewed. In vitro studies, pharmacokinetic trials in human subjects, and...
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