Article
Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting.
European journal of clinical pharmacology - 1 Jul 2004
Grasmäder Katja, Verwohlt Petra Louise, Rietschel Marcella, Dragicevic Aleksandra, Müller Matthias, Hiemke Christoph, Freymann Nikolaus, Zobel Astrid, Maier Wolfgang, Rao Marie Luise
Abstract excerpt
OBJECTIVE: This evaluation focuses on polymorphisms of the cytochrome-P450 (CYP) isoenzymes 2C9, 2C19 and 2D6 and their association with plasma concentrations within a typical clinical setting. Side effects and treatment response were analysed in an exploratory approach in poor and ultra-rapid metabolisers. PATIENTS AND METHODS: We analysed 136 Caucasian depressed inpatients treated with amitriptyline,...
Topics
- Antidepressive Agents
- Cytochrome P-450 Enzyme System
- Depressive Disorder
- Female
- Genotype
- Humans
- Isoenzymes
- Linear Models
- Male
- Middle Aged
- Pharmacogenetics
- Polymorphism, Genetic