Article

Pooled screening of CAR T cells identifies non-native signaling domains for next-generation immunotherapies

2021-07-12

Abstract excerpt

<h4>SUMMARY</h4> Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T cells to refractory cancers, but have shown limited efficacy against solid tumors. Here, we introduce ‘CAR Pooling’, a multiplexed approach to rapidly identify CAR designs with clinical potential. Forty CARs with diverse immune costimulatory domains were assessed in pooled assays for their ability to stimulate...

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Literature Corpus work: 15ff28db-8e5f-55c2-b07b-650f3f2214cb
DOI: 10.1101/2021.07.11.451980

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