Article

Pooled screening for CAR function identifies novel IL13Rα2-targeted CARs for treatment of glioblastoma

2024-04-09

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor therapies have demonstrated potent efficacy in treating B cell malignancies, but have yet to meaningfully translate to solid tumors. Here, we utilize our pooled screening platform, CARPOOL, to expedite the discovery of CARs with anti-tumor functions necessary for solid tumor efficacy. We performed selections in primary human T cells expressing a library of 1.3×10 6 3...

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Literature Corpus work: 50a31186-1a23-571e-8a6f-eb013ccab825
DOI: 10.1101/2024.04.04.586240

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