Article
Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale.
Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000
Wang Xiuli, Naranjo Araceli, Brown Christine E, Bautista Cherrilyn, Wong Chinglam W, Chang Wen-Chung, Aguilar Brenda, Ostberg Julie R, Riddell Stanley R, Forman Stephen J, Jensen Michael C
Abstract excerpt
A key determinant of the therapeutic potency of adoptive T-cell transfer is the extent to which infused cells can persist and expand in vivo. Ex vivo propagated virus-specific and chimeric antigen receptor (CAR)-redirected antitumor CD8 effector T cells derived from CD45RA(-) CD62L(+) central memory (TCM) precursors engraft long-term and reconstitute functional memory after adoptive transfer. Here, we describe a...
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