Article

Chimeric Antigen Receptors: A Paradigm Shift in Immunotherapy

2017-03-06

Abstract excerpt

Cancer immunotherapy is emerging as an effective and dependable approach to induce durable responses and survival benefit in several cancers. Two approaches, one based on antibody therapy to block immune inhibitory checkpoints and the other on the genetic engineering of T lymphocytes, have yielded dramatic clinical results in recent years, earning cancer immunotherapy the title “breakthrough of the year” by the jo...

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Identifiers and source

Literature Corpus work: 080b1385-1c05-521e-a94c-9927deaab4f2
DOI: 10.1146/annurev-cancerbio-050216-034351

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