Article

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors

2021-07-11

Abstract excerpt

CD19-targeted CAR therapies have successfully treated B cell leukemias and lymphomas, but many responders later relapse or experience toxicities. CAR intracellular domains (ICDs) are key to converting antigen recognition into anti-tumor effector functions. Despite the many possible immune signaling domain combinations that could be included in CARs, almost all CARs currently rely upon CD3 ζ , CD28, and/or 4-1BB s...

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Literature Corpus work: ec8b3d4b-d05e-5c52-9c88-5ce82b2fb04b
DOI: 10.1101/2021.07.09.450900

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