Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms.

doi:10.1186/s12885-015-1421-8

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms.

BMC cancer - 19 May 2015

Mackenzie Robertson, Kommoss Stefan, Winterhoff Boris J, Kipp Benjamin R, Garcia Joaquin J, Voss Jesse, Halling Kevin, Karnezis Anthony, Senz Janine, Yang Winnie, Prigge Elena-Sophie, Reuschenbach Miriam, Doeberitz Magnus Von Knebel, Gilks Blake C, Huntsman David G, Bakkum-Gamez Jamie, McAlpine Jessica N, Anglesio Michael S

Abstract excerpt

BACKGROUND: Mucinous ovarian tumors represent a distinct histotype of epithelial ovarian cancer. The rarest (2-4 % of ovarian carcinomas) of the five major histotypes, their genomic landscape remains poorly described. We undertook hotspot sequencing of 50 genes commonly mutated in human cancer across 69 mucinous ovarian tumors. Our goals were to establish the overall frequency of cancer-hotspot mutations across a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Mucinous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Ovarian Epithelial

Share to Mutation Rate

Share to Neoplasm Staging

Share to Neoplasms, Glandular and Epithelial

Share to Ovarian Neoplasms

Share to ras Proteins

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 25986173
DOI: 10.1186/s12885-015-1421-8
PMCID: PMC4494777

Genes

ERBB2
KRAS
BRAF
CTNNB1
FGFR2
GNA11
PTEN
SMAD4
SRC
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms.PMID 25986173Read ↗

Pre-invasive ovarian mucinous tumors are characterized by CDKN2A and RAS pathway aberrations.Semantic proximity Read ↗

Mutational Aberrations Detected in Mucinous Epithelial Ovarian Cancer of Asian Women.Semantic proximity Read ↗

Multipoint Kras oncogene mutations potentially indicate mucinous carcinoma on the entire spectrum of mucinous ovarian neoplasms.Semantic proximity Read ↗

Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes.Semantic proximity Read ↗

Molecular Genetic Analysis of Ovarian Brenner Tumors and Associated Mucinous Epithelial Neoplasms: High Variant Concordance and Identification of Mutually Exclusive RAS Driver Mutations and MYC Amplification.Semantic proximity Read ↗

Comprehensive genomic profiling reveals ubiquitous KRAS mutations and frequent PIK3CA mutations in ovarian seromucinous borderline tumor.Semantic proximity Read ↗

Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas.Semantic proximity Read ↗

Molecular characterization of serous ovarian carcinoma using a multigene next generation sequencing cancer panel approach.Semantic proximity Read ↗

Epithelial ovarian cancer: rationale for changing the one-fits-all standard treatment regimen to subtype-specific treatment.Semantic proximity Read ↗

Identification and clinical significance of somatic oncogenic mutations in epithelial ovarian cancer.Semantic proximity Read ↗

Endometrioid Versus Seromucinous Borderline Ovarian Tumors: Divergent Molecular Signatures and a Shared Role as Precursors to Endometrioid Carcinoma.Semantic proximity Read ↗

Molecular characterization of borderline and malignant Brenner tumors: implications for pathogenesis and therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.