Article
Multipoint Kras oncogene mutations potentially indicate mucinous carcinoma on the entire spectrum of mucinous ovarian neoplasms.
Oncotarget - 13 Dec 2016
Lee Yi-Ju, Lee Ming-Yung, Ruan Alexandra, Chen Chi-Kuan, Liu Hao-Ping, Wang Chau-Jong, Chao Wan-Ru, Han Chih-Ping
Abstract excerpt
Kras mutation is a common phenomenon in many human neoplasms. We aimed to assess the Kras mutational status along the histological continuum from normal ovaries to the development of benign, borderline and malignant ovarian mucinous neoplasms. We analyzed 41 cases of malignant, 10 cases of borderline, 7 cases of benign mucinous ovarian tumors and 7 cases of normal ovarian tissue. The prevalence of Kras mutations...
Topics
- Adenoma
- Biomarkers, Tumor
- Carcinoma
- Cell Transformation, Neoplastic
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Humans
- Mutation
- Neoplasms, Cystic, Mucinous, and Serous
- Ovarian Neoplasms
- Phenotype
- Proto-Oncogene Proteins p21(ras)