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Comprehensive genomic profiling reveals ubiquitous KRAS mutations and frequent PIK3CA mutations in ovarian seromucinous borderline tumor.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2020

Wu Ren-Chin, Chen Shu-Jen, Chen Hua-Chien, Tan Kien Thiam, Jung Shih-Ming, Lin Chiao-Yun, Chao An-Shine, Huang Kuan-Gen, Chou Hung-Hsueh, Chang Ting-Chang, Chao Angel, Lai Chyong-Huey

Abstract excerpt

The molecular underpinnings of seromucinous borderline tumor (SMBT) - an uncommon ovarian epithelial neoplasm characterized by association with endometriosis, frequent bilateral ovarian involvement, and occasional progression to invasive carcinoma - remain poorly understood. Here, we sought to comprehensively characterize the mutational landscape of SMBT and elucidate the clonal relationship between bilateral...

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PMID: 32616873
DOI: 10.1038/s41379-020-0611-3

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