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Article

Molecular characterization of borderline and malignant Brenner tumors: implications for pathogenesis and therapeutics.

Pathology, research and practice - 1 Jun 2026

Sun Yao, Shi Haiyan, Lu Bingjian

Abstract excerpt

Ovarian borderline (BrBT) and malignant (MBT) Brenner tumors are rare neoplasms frequently exhibiting mucinous metaplasia, yet their molecular drivers are poorly defined. To address this, we performed a clinicopathological and molecular study on two cases each BrBT and MBT by immunohistochemistry, fluorescence in situ hybridization, and next-generation sequencing. Recurrent alterations included CDKN2A/CDKN2B...

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Topics

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Share to Adenocarcinoma, Mucinous
Share to Biomarkers, Tumor
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CDKN2A gene

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Share to Ovarian Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Share to Receptor, Fibroblast Growth Factor, Type 3

Source

Identifiers

PMID: 41887053
DOI: 10.1016/j.prp.2026.156446

Genes

KRAS
PIK3CA
CDKN2A
CDKN2B
FGFR3
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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